![]() The unvaccinated control group consisted of SARS-CoV-2 positive cases in our healthcare system who had not received a dose of any vaccine at the time of RT-PCR positivity, collected and sequenced in the same period as the breakthrough infections. Vaccine breakthroughs were defined by positive real-time (RT)-PCR test for SARS-CoV-2 RNA regardless of Ct at least 14 days after the second dose of BNT162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) vaccines, or the single-dose COVID-19 Janssen vaccine. Cases were identified using DataCore, the system's clinical data management and extraction resource. ![]() SARS-CoV-2 infections were studied in vaccinated and unvaccinated individuals from May 1st until August 3 rd in the NYULH system. This study was approved by the NYULH Institutional Review Board, protocol numbers i21-00493 and i21-00561. Emerging SARS-CoV-2 variants will require close monitoring and should include mutation hotspot regions such as the spike N-terminal domain with the S112L mutation as well as nsp12 mutations such as F192V that we found in increased numbers among vaccine breakthroughs. The significant increase of Delta infections relative to time since vaccination highlights Delta's improved potential of epidemic growth in times of waning vaccine protection, backing the implementation of booster vaccinations in the broader population. Nevertheless, we found subtle but significant differences in the SARS-CoV-2 mutation profiles in breakthrough infections compared with unvaccinated controls including two enriched and seven decreased mutations, suggesting that selective adaptation was in process that might have played a supportive role. The low percentage of vaccine breakthrough infections compared to the total number of vaccinated individuals at NYU and New York City-wide during the time of Delta predominance underline the effectiveness of COVID-19 vaccines against infection with Delta and previous variants. ![]() The Lancet Regional Health – Western PacificĪfter adjusting for confounding variables, we observed that the frequency of Delta infections rose at a similar pace in unvaccinated and vaccinated individuals, which indicates that Delta and its mutations had a limited impact on vaccine escape when compared with other co-circulating variants. ![]() The Lancet Regional Health – Southeast Asia.The Lancet Gastroenterology & Hepatology. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |